• HPE Cray Supercomputing GX5000, featuring 6th Gen AMD EPYC™ processors, delivers 40% more core density in one rack compared to current market offerings¹, 25% less data center space² and 25% warmer facility water³ to improve overall operational efficiency 
• HPE delivers HPE Cray Supercomputing GX5000 as fully integrated systems, combining state-of-the-art CPUs, accelerators, storage, networking, software and direct liquid cooling
• Early adopters of GX5000 with new AMD EPYC CPUs include Oak Ridge National Laboratory and the High-Performance Computing Center of the University of Stuttgart (HLRS)

Today, at AMD Advancing AI 2026 in San Francisco, HPE showcased its latest engineering innovation in supercomputing with the HPE Cray Supercomputing GX5000 featuring 6^th Gen AMD EPYC processors.

The GX5000 builds on the success of previous HPE supercomputing architecture that broke the exascale speed barrier, and dominates the world’s top 10 list of fastest supercomputers, to support the most complex scientific and engineering problems involving AI and quantum.

The GX5000 delivers the industry’s highest density performance with 40% more AMD EPYC 9996 cores per rack than the market’s next densest offering.¹ The GX5000 also maximizes capacity for growing HPC and AI workloads and improves operational efficiency by reducing carbon footprint with 25% less floor space compared to the previous generation² and an increase of warm facility water by 25%, with up to 40C heating capacity, through next-generation direct-liquid cooling capabilities from HPE.

HPE Cray Supercomputing GX5000: built for a new era of AI-driven scienceHPE Cray Supercomputing GX5000 will power next-generation exascale and leadership-class supercomputers that HPE builds as fully integrated systems spanning state-of-the-art CPUs, accelerators, storage, networking, software and 100% direct-liquid cooling.

The GX5000 was designed to support converged HPC workloads, like modeling and simulation, with AI, to accelerate scientific discovery across areas such as drug discovery, climate forecasting and materials science.

GX5000 systems also address growing requirements for secure multi-tenant capabilities to manage user control while enabling access to bolster collaboration. 

World-leading supercomputing and research centers are adopting GX5000 with 6th Gen AMD EPYC processors to make breakthroughs in AI and quantum-driven applications scientific discoveries.

Early adopters of HPE Cray Supercomputing GX5000 take on new missions in AI and quantumWorld-leading supercomputing and research centers are adopting GX5000 with 6^th Gen AMD EPYC processors to make breakthroughs in AI and quantum-driven applications scientific discoveries.

Early adopters include Oak Ridge National Laboratory (ORNL) and the High-Performance Computing Center of the University of Stuttgart (HLRS).

Oak Ridge National Laboratory expands exascale capabilities for open science with “Discovery”After ushering in the world’s first exascale supercomputer, Frontier, Oak Ridge National Laboratory (ORNL), HPE, and AMD are partnering again to deliver an even more powerful exascale machine with Discovery, an HPE Cray Supercomputing GX5000 system with new AMD EPYC processors.

Discovery will support a mix of converged simulation and AI workloads, AI model development and training, and serve as a testbed for ORNL’s ongoing efforts in quantum computing.

ORNL, HPE and AMD are also building a dedicated AI system, called “Lux,” using next generation HPE systems featuring 6^th Gen AMD EPYC processors. Lux will accelerate AI development, as part of the U.S. Genesis Mission, to strengthen national security and competitiveness.

HLRS boosts Germany’s research and manufacturing efforts with next-generation supercomputer “Herder”HPE and HLRS, one of Germany’s leading research centers, are continuing a years-long partnership of designing and delivering cutting-edge supercomputers with HLRS’ upcoming flagship system, “Herder.”

Herder, a GX5000 system with new AMD EPYC CPUs, is expected to be 7X more powerful than HLRS’ current supercomputer, to bolster German and European research and advance industrial innovation.

The system will support a growing demand in computational science for converged simulation and AI capabilities, and advance AI model training.

HPE Cray Supercomputing GX5000 supports a range of mixed-precision and double-precision computing workloadsThe HPE Cray Supercomputing GX5000, featuring 6^th Gen AMD EPYC processors, is offered as two blade options to support demands in traditional supercomputing workloads, like modeling and simulation, and AI capabilities like model development, training, and tuning. 

• HPE Cray Supercomputing GX350a Accelerated Blade: A mixed-precision computing blade that combines one 6^th Gen AMD EPYC processor with four AMD Instinct MI430X GPUs, supporting up to 112 AMD GPUs per rack.  

• HPE Cray Supercomputing GX250 Compute Blade: A CPU-only blade targeted for double-precision workloads that features eight 6^th Gen AMD EPYC processors. A single rack can house 40 nodes to support extreme density with 81,920 CPU cores.