Mental fatigue is a leading cause of motor vehicle accidents, medical errors, loss of workplace productivity, and student disengagements in e-learning environment. Development of sensors and systems that can reliably track mental fatigue can prevent accidents, reduce errors, and help increase workplace productivity. This review provides a critical summary of theoretical models of mental fatigue, a description of key enabling sensor technologies, and a systematic review of recent studies using biosensor-based systems for tracking mental fatigue in humans. We conducted a systematic search and review of recent literature which focused on detection and tracking of mental fatigue in humans. The search yielded 57 studies (N=1082), majority of which used electroencephalography (EEG) based sensors for tracking mental fatigue. We found that EEG-based sensors can provide a moderate to good sensitivity for fatigue detection. Notably, we found no incremental benefit of using high-density EEG sensors for application in mental fatigue detection. Given the findings, we provide a critical discussion on the integration of wearable EEG and ambient sensors in the context of achieving real-world monitoring. Future work required to advance and adapt the technologies toward widespread deployment of wearable sensors and systems for fatigue monitoring in semi-autonomous and autonomous industries is examined.