Building effective, enjoyable, and safe autonomous vehicles is a lot harder than has historically been considered. The reason is that, simply put, an autonomous vehicle must interact with human beings. This interaction is not a robotics problem nor a machine learning problem nor a psychology problem nor an economics problem nor a policy problem. It is all of these problems put into one. It challenges our assumptions about the limitations of human beings at their worst and the capabilities of artificial intelligence systems at their best. This work proposes a set of principles for designing and building autonomous vehicles in a human-centered way that does not run away from the complexity of human nature but instead embraces it. We describe our development of the Human-Centered Autonomous Vehicle (HCAV) as an illustrative case study of implementing these principles in practice.