惯性聚合 高效追踪和阅读你感兴趣的博客、新闻、科技资讯
阅读原文 在惯性聚合中打开

推荐订阅源

MongoDB | Blog
MongoDB | Blog
大猫的无限游戏
大猫的无限游戏
H
Help Net Security
V
Visual Studio Blog
G
Google Developers Blog
Blog — PlanetScale
Blog — PlanetScale
Last Week in AI
Last Week in AI
C
Check Point Blog
D
Docker
M
MIT News - Artificial intelligence
P
Proofpoint News Feed
博客园 - 叶小钗
博客园 - 聂微东
The Cloudflare Blog
云风的 BLOG
云风的 BLOG
Martin Fowler
Martin Fowler
OSCHINA 社区最新新闻
OSCHINA 社区最新新闻
酷 壳 – CoolShell
酷 壳 – CoolShell
MyScale Blog
MyScale Blog
WordPress大学
WordPress大学
Engineering at Meta
Engineering at Meta
腾讯CDC
S
SegmentFault 最新的问题
博客园 - 【当耐特】

cs.DS updates on arXiv.org

PAC Learning with Bandit Feedback: Sharp Sample Complexity in the Realizable Setting Algorithms with Polynomially-Improved Approximation Factors for the $2 \rightarrow q$ Norm, and Applications A computational phase transition for learning-to-sample from Ising models Covering vertices by sequential stars Fermi-Dirac machines as quantizations of neurons A Comprehensive Evaluation of Vertex Elimination Algorithms for Algorithmic Differentiation A Tight Bound on Localization of Electrical Flows Optimal Dimension-Free Sampling for Regularized Classification Reducing the Randomness in Partition Oracles for Bounded Degree Minor-Free Graphs Beyond the Half-Approximation: Fair and Efficient Online Class Matching Efficient Uniform Sampling of Surjections via their Profiles Tractable Maximization of Budgeted Phylogenetic Diversity on Networks Utilizing Node Scanwidth Fairness in Aggregation: Optimal Top-$k$ and Improved Full Ranking Learning-Augmented Online Scheduling with Parsimonious Preemption Entropy Equivalence Testing Lumberjack: Better Differentially Private Random Forests through Heavy Hitter Detection in Trees The Secretary Problem with a Stochastic Precursor Polynomial-Time Robust Multiclass Linear Classification under Gaussian Marginals Efficient Banzhaf-Based Data Valuation for $k$-Nearest Neighbors Classification Block-Sphere Vector Quantization An Approximation Algorithm for Graph Label Selection Iterative Chow Filtering for Learning with Distribution Shift Complexity of Non-Log-Concave Sampling in Fisher Information Stochastic Matching via Local Sparsification Finite Sample Bounds for Learning with Score Matching What is Learnable in Valiant's Theory of the Learnable? Provable Quantization with Randomized Hadamard Transform Min-Max Optimization Requires Exponentially Many Queries Fast and Compact Graph Cuts for the Boykov-Kolmogorov Algorithm A proximal gradient algorithm for composite log-concave sampling
Incorporating indel channels into average-case analysis o...
Spencer Gibson, Yun William Yu · 2025-12-05 · via cs.DS updates on arXiv.org

Given a sequence $s_1$ of $n$ letters drawn i.i.d. from an alphabet of size $σ$ and a mutated substring $s_2$ of length $m < n$, we often want to recover the mutation history that generated $s_2$ from $s_1$. Modern sequence aligners are widely used for this task, and many employ the seed-chain-extend heuristic with $k$-mer seeds. Previously, Shaw and Yu showed that optimal linear-gap cost chaining can produce a chain with $1 - O\left(\frac{1}{\sqrt{m}}\right)$ recoverability, the proportion of the mutation history that is recovered, in $O\left(mn^{2.43θ} \log n\right)$ expected time, where $θ< 0.206$ is the mutation rate under a substitution-only channel and $s_1$ is assumed to be uniformly random. However, a gap remains between theory and practice, since real genomic data includes insertions and deletions (indels), and yet seed-chain-extend remains effective. In this paper, we generalize those prior results by introducing mathematical machinery to deal with the two new obstacles introduced by indel channels: the dependence of neighboring anchors and the presence of anchors that are only partially correct. We are thus able to prove that the expected recoverability of an optimal chain is $\ge 1 - O\Bigl(\frac{1}{\sqrt{m}}\Bigr)$ and the expected runtime is $O(mn^{3.15 \cdot θ_T}\log n)$, when the total mutation rate given by the sum of the substitution, insertion, and deletion mutation rates ($θ_T = θ_i + θ_d + θ_s$) is less than $0.159$.