We consider the problem of human-assisted graph search: given a directed acyclic graph with some (unknown) target node(s), we consider the problem of finding the target node(s) by asking an omniscient human questions of the form "Is there a target node that is reachable from the current node?". This general problem has applications in many domains that can utilize human intelligence, including curation of hierarchies, debugging workflows, image segmentation and categorization, interactive search and filter synthesis. To our knowledge, this work provides the first formal algorithmic study of the optimization of human computation for this problem. We study various dimensions of the problem space, providing algorithms and complexity results. Our framework and algorithms can be used in the design of an optimizer for crowd-sourcing platforms such as Mechanical Turk.