We introduce several generalizations of classical computer science problems obtained by replacing simpler objective functions with general submodular functions. The new problems include submodular load balancing, which generalizes load balancing or minimum-makespan scheduling, submodular sparsest cut and submodular balanced cut, which generalize their respective graph cut problems, as well as submodular function minimization with a cardinality lower bound. We establish upper and lower bounds for the approximability of these problems with a polynomial number of queries to a function-value oracle. The approximation guarantees for most of our algorithms are of the order of sqrt(n/ln n). We show that this is the inherent difficulty of the problems by proving matching lower bounds. We also give an improved lower bound for the problem of approximately learning a monotone submodular function. In addition, we present an algorithm for approximately learning submodular functions with special structure, whose guarantee is close to the lower bound. Although quite restrictive, the class of functions with this structure includes the ones that are used for lower bounds both by us and in previous work. This demonstrates that if there are significantly stronger lower bounds for this problem, they rely on more general submodular functions.