A well-known approach in the design of efficient algorithms, called matrix sparsification, approximates a matrix $A$ with a sparse matrix $A'$. Achlioptas and McSherry [2007] initiated a long line of work on spectral-norm sparsification, which aims to guarantee that $\|A'-A\|\leq ε\|A\|$ for error parameter $ε>0$. Various forms of matrix approximation motivate considering this problem with a guarantee according to the Schatten $p$-norm for general $p$, which includes the spectral norm as the special case $p=\infty$. We investigate the relation between fixed but different $p\neq q$, that is, whether sparsification in the Schatten $p$-norm implies (existentially and/or algorithmically) sparsification in the Schatten $q\text{-norm}$ with similar sparsity. An affirmative answer could be tremendously useful, as it will identify which value of $p$ to focus on. Our main finding is a surprising contrast between this question and the analogous case of $\ell_p$-norm sparsification for vectors: For vectors, the answer is affirmative for $p<q$ and negative for $p>q$, but for matrices we answer negatively for almost all sufficiently distinct $p\neq q$. In addition, our explicit constructions may be of independent interest.