Given two sets of points A and B, $|A| = m$, $|B| = n$, the Chamfer distance from $A$ to $B$ is defined as $\operatorname{CD}(A,B) = \sum_{a\in A} \min_{b\in B} d(a,b)$, where $d$ is a distance metric. Chamfer distance is a popular measure of dissimilarity between two sets of points that has seen increasing usage in computer vision and information retrieval as a substitute for the more computationally demanding Earth Mover's distance. We propose a new problem, Chamfer distance under translation, defined as $\operatorname{CDuT}(A,B) :=\min_{t\in \mathbb{R}^d} \operatorname{CD}(A+t,B)$, where $A+t$ denotes the translation of every point in $A$ by $t$. Chamfer distance under translation is valuable in cases where translations capture aspects of the data unlikely to be relevant for dissimilarity, such as temporal, spatial, or other semantic information. For Chamfer distance under translation, we provide four algorithms: (1) an exact quadratic time algorithm in one dimension, (2) a near quadratic time ($2+\varepsilon$)-approximation algorithm in higher dimensions, (3) a $(1+\varepsilon)$-approximation algorithm with running time $\mathcal{O}(mn^2\varepsilon^{-(d+1)})$, and (4) a near-quadratic time $(1+\varepsilon)$-approximation algorithm for answering the decision version of $\operatorname{CDuT}$ given a separation assumption on $B$. We additionally explore the fine-grained complexity of $\operatorname{CDuT}$.