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MLB Picks: Best Strikeout Prop Bets for Friday 6/5/26
Sam Connon · 2026-06-06 · via DraftKings Network

Jesus Luzardo is looking to guide the Phillies over the White Sox, while Red Sox veteran Sonny Gray and Mets standout Christian Scott are also set to take the bump Friday. Sam Connon shares his picks and predictions in regards to the three starting pitchers’ strikeout prop bets.

There are a handful of aces taking the mound Friday, including surprise standout Christian Scott and veterans Jesus Luzardo and Sonny Gray. DraftKings Sportsbook has strikeout prop bets for all three of them, so we made our picks for the best bets, too. Can Gray get revenge against his former team with the Red Sox taking on the Yankees? Will Luzardo keep the Phillies in the win column? Is Scott going to deal yet another gem? Here is our full breakdown of where we think each starting pitcher will wind up in the strikeout column.

Best MLB Strikeout Prop Bets Today (June 5, 2026)

  • Philadelphia Phillies vs. Chicago White Sox: Phillies LHP Jesus Luzardo under 6.5 strikeouts: Luzardo has come up short of 6.5 K in 5 straight appearances heading into his showdown with a White Sox offense that is heating up and could chase him off the mound early.
  • New York Yankees vs. Boston Red Sox: Red Sox RHP Sonny Gray 6+ strikeouts: Going against his former team in the Yankees, who are now without superstar slugger Aaron Judge for the next 4-6 weeks, I like Gray to go deep into the contest and hit 6+ K for the 4th time in his last 5 starts.
  • San Diego Padres vs. New York Mets: Mets RHP Christian Scott 5+ strikeouts: Scott has posted 5+ K in six consecutive starts, averaging 11.3 K/9 on the season, and now he is set to face a Padres lineup that has the lowest OPS+ in MLB and likely won’t get to him early enough to keep the strikeout total down.

MLB Strikeout Prop Bets Breakdown

Jesus Luzardo under 6.5 K (-114), Philadelphia Phillies vs. Chicago White Sox

For the fourth time in five seasons, Luzardo is averaging double-digit strikeouts per nine innings. And while he went over 6.5 punchouts in five of his first seven starts this season, the southpaw has come in under that mark in five straight outings. Luzardo getting chased out after 3.0 frames on May 8 made the under effectively inevitable, but he has pitched into the sixth inning in four straight and still failed to clear 6.5 strikeouts. Going against a White Sox lineup that is averaging 6.5 runs per game since May 27, there’s a good chance that Luzardo doesn’t even last that long anyways. Chicago also has a .771 team OPS against lefties like Luzardo compared to their .722 mark against righties, striking out at around a 24% clip against both.

Sonny Gray 6+ K (+104), New York Yankees vs. Boston Red Sox

Gray started slow this season, averaging just 2.5 strikeouts between his first six appearances in a Red Sox uniform. He has since come into his own, though, averaging 6.5 and going for 6+ punchouts in three of his last four starts. Gray posted a 2.00 ERA in the month of May, and he has a 1.93 ERA this season against all teams that aren’t the Twins. Minnesota has his number, but hardly anyone else does. And now that the Yankees have lost All-Star outfielder Aaron Judge to a rib injury for 4-to-6 weeks, this could be the perfect opportunity for Gray to get some revenge against one of his former teams. Gray averaged at last 10 strikeouts per nine innings in both 2024 and 2025, and perhaps he rides his recent groove back into that level of production on Friday.

Christian Scott 5+ K (-173), San Diego Padres vs. New York Mets

After missing all of 2025 recovering from Tommy John surgery, Scott has battled back with a vengeance here in 2026. He owns a 2.97 ERA through seven starts, and the Mets are 5-2 when he takes the mound. Even Scott’s 3.10 FIP shows that his success is pretty closely aligned with his expected production, and now he is going against a Padres offense that ranks dead-last in MLB with an 84 OPS+. While the Padres are league average when it comes to striking out, Scott went for 5+ punchouts in all six of his starts in May. He even reached eight strikeouts in two of those outings, so there’s a solid ceiling there as well. At 11.3 strikeouts per nine innings, Scott should really only need to pitch into the fifth inning – something he has done in five of his alst six starts – to comfortable reach 5+ K on Friday.

More MLB Betting Content & Picks

Check out more MLB betting content and player props throughout the season on DraftKings Network.

Good luck with your MLB prop bets today!