The MLB season is rolling along. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings is Pick6 Fantasy Baseball!

Here are my top Pick6 plays for today’s MLB slate.

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DraftKings MLB Pick6 Plays

Bryce Harper More Than 1.5 Total Bases

Bryce Harper is on fire at the plate at the moment. Over the past week, he has batted .458 with a 1.375 OPS. Over the past 15 days, he has batted .304 with a 1.002 OPS. He should keep it rolling in this game against Miles Mikolas. Harper has a 1.036 OPS against right-handed pitching this season. It has also been a season to forget for Miles Mikolas. He has a 5.47 ERA and a 1.28 WHIP in 2026. Mikolas has been even worse at home, where he has a 6.37 ERA this season. Harper has hit Mikolas hard in the past as well. He has a .360 batting average and a 1.065 OPS in 25 career at-bats against Mikolas. If it comes down to it, the Nationals also have the fourth-worst bullpen ERA in the MLB this season. Harper should keep his hot streak going and take advantage of this matchup against Miles Mikolas and the Nationals.

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Jac Caglianone More Than 1.5 Hits + Runs + RBIs

Jac Caglianone is one of the hottest hitters in baseball at the moment. He has six home runs in his past five games, including two home runs last night against Tampa Bay. Over the past week, Caglianone has a ridiculous 1.431 OPS. However, he has been great this entire month. In June, Caglianone has a 1.227 OPS. He should keep it going tonight against Griffin Jax, and the Rays. Jax has a 3.67 ERA and a 1.31 WHIP this season. Jax has been mostly solid against right-handed hitters, but has really struggled against lefties. Left-handed hitters are batting .282 with an .830 OPS against Jax this season. Once it gets to the bullpen, the Rays have a 4.62 bullpen ERA, the eighth-worst mark in baseball. Jac Caglianone should keep his hot streak going and get over this number against the Rays.

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Joe Ryan More Than 5.5 Strikeouts Thrown

Joe Ryan is putting together an excellent season for the Twins. He has a 1.00 WHIP, the sixth-best mark among qualified pitchers. Ryan also has a 2.99 ERA, the 14th-best mark among qualified pitchers. Ryan is also averaging 10.2 K/9. His 99 total strikeouts are the 13th-most in baseball this season. This is always a tough matchup against the Dodgers, but Ryan should hold his own. Ryan will be at home for this start, where he has been even better this season. His ERA in Minnesota in 2026 is 2.85. Ryan should get to six strikeouts in this start against the Dodgers. Joe Ryan has struck out at least seven batters in six of his past seven starts. He should keep that momentum going and strike out at least six in this one.

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What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether or not you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.

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Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!

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Gambling Problem? Call 1-800-GAMBLER. Must be at least 18 years or older. Higher age limits may apply in some states. Eligibility restrictions apply. Valid only in states where DraftKings Pick6 operates. Void where prohibited. For entertainment purposes only. Winning a contest on DraftKings depends on knowledge and exercise of skill. See terms at pick6.draftkings.com.

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