Support vector machine (SVM) is a powerful machine learning algorithm to handle classification tasks. However, the classical SVM is developed for binary problems with the assumption of balanced datasets. Obviously, the multi-class imbalanced classification problems are more complex. In this paper, we propose an improved SVM via Differential Evolution (i-SVM-DE) method to deal with it. An improved SVM (i-SVM) model is proposed to handle the data imbalance by combining cost sensitive technique and separation margin modification in the constraints, which formalize a parameter optimization problem. By using one-versus-one (OVO) scheme, a multi-class problem is decomposed into a number of binary subproblems. A large optimization problem is formalized through concatenating the parameters in the binary subproblems. To find the optimal model effectively and learn the support vectors for each class simultaneously, an improved differential evolution (DE) algorithm is applied to solve this large optimization problem. Instead of the validation set, we propose the fitness functions to evaluate the learned model and obtain the optimal parameters in the search process of DE. A series of experiments are carried out to verify the benefits of our proposed method. The results indicate that i-SVM-DE is statistically superior by comparing with the other baseline methods.