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NIST Sesame Reference Material Initiative – Call to Collaborate NIST/NIBIB Symposium on Medical Metrology and Standards for American Healthcare and Commerce NIST Receives New Patent for Microbe-Killing Water Heater Spotlight: How NIST Helps Make Sure the Fish You Catch Are Safe to Eat NIST Expands Its Library of ‘Chemical Fingerprints’ to Identify Unknown Substances SRM Story: SRM 1947a Great Lakes Fish Tissue SRM Story: SRMs 3672a and 3673a Organic Contaminants in Smokers’ and Nonsmokers’ Urine Space: The Final Frontier for Standards Securing Smart Speakers for Home Health Care: NIST Offers New Guidelines NIST’s ‘Living Reference Material’ Could Accelerate R&D of Lifesaving Biological Drugs NIST Awards Over $1.8 Million to Small Businesses Advancing AI, Semiconductors, Additive Manufacturing and More SRM Story: SRM 965c Glucose in Frozen Human Serum Second Seminar on Building an In-Space Circular Economy New NIST Reference Material to Strengthen Quality Control for Biological Drugs NIST Releases Trove of Genetic Data to Spur Cancer Research New NIST Research Grade Test Material to support mRNA therapeutics NIST Shares Preliminary Findings From Hurricane Maria Investigation New NIST Standard Helps Deliver the Right Dosage of Cancer-Fighting Drugs Second Series of Workshops on Measurements and Standards for Advanced Therapy NIST Researcher Addresses London Healthcare Innovation Forum NIST Releases Reference Material to Aid Gut Microbiome Research NIST Researchers Develop Material for Measuring Arsenic in Shellfish 2025 NIST Workshop on Rapid Microbial Testing Methods An SRM for Accuracy in Electrolyte Panel Clinical Tests Study Highlights Need for Standardized Measurement Methods in Gene Therapy NIST Develops Genetic Material for Validating H5N1 Bird Flu Diagnostic Tests PFAS Found in Firefighter Gloves, Hoods and Wildland Gear AI and Flow Cytometry Workshop Genome Editing Consortium Workshop Social Spotlight: Engineered Cells as a Shoebox
Spotlight: Game-Changing Microscopy Technique for Identif...
2024-09-03 · via News and Events Feed by Topic
Freshly dissected tissue (lower left) and its pathology-prepared slide with identified tumor regions by a pathologist (upper left), and a pseudo-color image of hyperspectral dark-field microscopy (HSDFM) data cube (middle) region marked on the tissue images on the left.

Credit: J. Hwang/NIST

Breast-conserving surgery, or lumpectomy, is a treatment for early-stage breast cancer. It’s important for surgeons to remove enough tissue around the tumor to ensure that no cancer cells are left, but still conserve the surrounding healthy tissue as much as possible. Traditionally, this requires a slow process of staining and examining tissue under a microscope.

Researchers at NIST have developed a faster imaging method using hyperspectral dark-field microscopy. This technique uses different wavelengths of light to distinguish between cancerous and healthy cells without staining. It can be used on fresh tissue samples during surgery, providing immediate feedback to the surgeon. This reduces the need for follow-up surgeries by ensuring that all cancerous tissue is removed in the first operation.

This new method, combined with machine learning, accurately identifies cancer cells and could greatly improve breast cancer treatment and patient care. 

As breast cancer remains a leading cause of cancer-related deaths in women, innovations like these are crucial in improving treatment and overall patient care.

Learn more about the method.