Retrieval-Augmented Generation (RAG) systems depend on the geometric properties of vector representations to retrieve contextually appropriate evidence. When source documents interleave multiple topics within contiguous text, standard vectorization produces embedding spaces in which semantically distinct content occupies overlapping neighborhoods. We term this condition semantic entanglement. We formalize entanglement as a model-relative measure of cross-topic overlap in embedding space and define an Entanglement Index (EI) as a quantitative proxy. We argue that higher EI constrains attainable Top-K retrieval precision under cosine similarity retrieval. To address this, we introduce the Semantic Disentanglement Pipeline (SDP), a four-stage preprocessing framework that restructures documents prior to embedding. We further propose context-conditioned preprocessing, in which document structure is shaped by patterns of operational use, and a continuous feedback mechanism that adapts document structure based on agent performance. We evaluate SDP on a real-world enterprise healthcare knowledge base comprising over 2,000 documents across approximately 25 sub-domains. Top-K retrieval precision improves from approximately 32% under fixed-token chunking to approximately 82% under SDP, while mean EI decreases from 0.71 to 0.14. We do not claim that entanglement fully explains RAG failure, but that it captures a distinct preprocessing failure mode that downstream optimization cannot reliably correct once encoded into the vector space.