Human interaction is inherently multimodal and full-duplex: we listen while watching, speak while acting, and fluidly adapt to turn-taking and interruptions. Realizing these capabilities is essential for building models simulating humans. We present ELLSA (End-to-end Listen, Look, Speak and Act), which, to our knowledge, is the first full-duplex, end-to-end model that simultaneously perceives and generates across vision, text, speech, and action within a single architecture, enabling interaction patterns previously out of reach, yielding more natural, human-like behaviors. At its core is a novel SA-MoE architecture (Self-Attention Mixture-of-Experts) that routes each modality to specialized experts and fuses them through a unified attention backbone. This provides a generalizable solution for joint multimodal perception and concurrent generation, leveraging strong pre-trained components while enabling efficient modality integration and mitigating modality interference. On speech-interaction and robot-manipulation benchmarks, ELLSA matches modality-specific baselines, while uniquely supporting advanced multimodal and full-duplex behaviors such as dialogue and action turn-taking, defective instruction rejection, speaking-while-acting, context-grounded visual question answering, and action barge-ins. We contend that ELLSA represents a step toward more natural and general interactive intelligence, contributing to the broader pursuit of artificial general intelligence. All data, code and model checkpoints will be released at https://github.com/bytedance/SALMONN/tree/ELLSA.