In the era of large-scale pre-trained models, effectively adapting general knowledge to specific affective computing tasks remains a challenge, particularly regarding computational efficiency and multimodal heterogeneity. While Transformer-based methods have excelled at modeling inter-modal dependencies, their quadratic computational complexity limits their use with long-sequence data. Mamba-based models have emerged as a computationally efficient alternative; however, their inherent sequential scanning mechanism struggles to capture the global, non-sequential relationships that are crucial for effective cross-modal alignment. To address these limitations, we propose \textbf{AlignMamba-2}, an effective and efficient framework for multimodal fusion and sentiment analysis. Our approach introduces a dual alignment strategy that regularizes the model using both Optimal Transport distance and Maximum Mean Discrepancy, promoting geometric and statistical consistency between modalities without incurring any inference-time overhead. More importantly, we design a Modality-Aware Mamba layer, which employs a Mixture-of-Experts architecture with modality-specific and modality-shared experts to explicitly handle data heterogeneity during the fusion process. Extensive experiments on four challenging benchmarks, including dynamic time-series (on the CMU-MOSI and CMU-MOSEI datasets) and static image-related tasks (on the NYU-Depth V2 and MVSA-Single datasets), demonstrate that AlignMamba-2 establishes a new state-of-the-art in both effectiveness and efficiency across diverse pattern recognition tasks, ranging from dynamic time-series analysis to static image-text classification.