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错误信息：

HTTP Error 500.19 - Internal Server Error
The requested page cannot be accessed because the related configuration data for the page is invalid.
Detailed Error Information
Module : IIS Web Core Requested URL: http://localhost:80/
Notification: Unknown Physical Path:
Handler : Not yet determined Logon Method : Not yet determined
Error Code : 0x80070005 Logon User : Not yet determined
Config Error: Cannot read configuration file due to insufficient permissions

解决办法：给站点跟目录添加权限IIS_USER的权限，允许该用户修改即可。