In this paper, we aim to replace in the definitions of covariance and correlation the usual trace {\rm Tr} by a tracial positive map between unital $C^*$-algebras and to replace the functions $x^α$ and $x^{1-α}$ by functions $f$ and $g$ satisfying some mild conditions. These allow us to define the generalized covariance, the generalized variance, the generalized correlation and the generalized Wigner--Yanase--Dyson skew information related to the tracial positive maps and functions $f$ and $g$. We persent a generalization of Heisenberg's uncertainty relation in the noncommutative framework. We extend some inequalities and properties for the generalized correlation and the generalized Wigner--Yanase--Dyson skew information. Furthermore, we extend some inequalities for the generalized skew information such as uncertainty relation and the relation between the generalized variance and the generalized skew information.