Abstract:This paper studies information rates of noisy duplication channels with memory, motivated by nanopore DNA sequencing. In nanopore sequencing, the measured signal is affected by both inter-symbol interference (ISI), caused by multiple DNA bases residing in the pore, and random sample duplications, where variable translocation speed causes each base to generate a random number of samples. These two effects make direct theoretical analysis difficult. To address this, we derive a new decomposition of the information rate into two interpretable terms: one capturing the channel memory through an auxiliary ISI channel, and another capturing the uncertainty in the segment boundaries caused by random duplications. This decomposition separates the dominant channel distortions and replaces the direct analysis of the full channel with two more readily tractable components. We then study the second term through a soft alignment functional closely related to Soft-DTW, which yields a strong asymptotic equipartition property result and an alternative proof of the Markov-constrained coding theorem. Finally, we develop a lower bound on the information rate that depends on the distribution of jump distances between adjacent nanopore levels. This bound gives a simple geometric explanation of channel synchronisability and provides a tractable framework for computing achievable rates of Oxford nanopore sequencers.
From: Brendon McBain Dr [view email]
[v1]
Fri, 5 Jun 2026 01:21:38 UTC (179 KB)
[v2]
Mon, 7 Sep 2026 00:17:17 UTC (218 KB)
此内容由惯性聚合(RSS阅读器)自动聚合整理，仅供阅读参考。 原文来自 — 版权归原作者所有。