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Theoretical Limits of Language Model Alignment $f$-Divergence Regularized RLHF: Two Tales of Sampling and Unified Analyses A Unified Measure-Theoretic View of Diffusion, Score-Based, and Flow Matching Generative Models When Can Voting Help, Hurt, or Change Course? Exact Structure of Binary Test-Time Aggregation When Semantic Communication Meets Queueing: Cross-Layer Latency and Task Fidelity Optimization Convexity in Disguise: A Theoretical Framework for Nonconvex Low-Rank Matrix Estimation Conditional Diffusion Under Linear Constraints: Langevin Mixing and Information-Theoretic Guarantees Sharp Capacity Thresholds in Linear Associative Memory: From Winner-Take-All to Listwise Retrieval Expert Routing for Communication-Efficient MoE via Finite Expert Banks Contextual Memory-Enhanced Source Coding for Low-SNR Communications Realizable Bayes-Consistency for General Metric Losses Leveraging Code Automorphisms for Improved Syndrome-Based Neural Decoding A Hierarchical Sampling Framework for bounding the Generalization Error of Federated Learning Dueling DDQN-Based Adaptive Multi-Objective Handover Optimization for LEO Satellite Networks The Causal Description Gap: Information-Theoretic Separations Across Pearl's Hierarchy Optimization of CV-QKD Under Practical Constraints Benchmarking Wireless Representations: High-Dimensional vs. Compressed Embeddings for Efficiency and Robustness Real-Time Text Transmission via LLM-Based Entropy Coding over Fixed-Rate Channels SwiftChannel: Algorithm-Hardware Co-Design for Deep Learning-Based 5G Channel Estimation Evolving Token Communication with Parametric Memory Network Remote Action Generation: Remote Control with Minimal Communication The (Marginal) Value of a Search Ad: An Online Causal Framework for Repeated Second-price Auctions Stabilizing Private LASSO under Heterogeneous Covariates via Anisotropic Objective Perturbation Linear-Readout Floors and Threshold Recovery in Computation in Superposition Soft Graph Diffusion Transformer for MIMO Detection Hierarchical Federated Learning for Networked AI: From Communication Saving to Architecture-Aware Design Exponential families from a single KL identity MIFair: A Mutual-Information Framework for Intersectionality and Multiclass Fairness Diffusion-OAMP for Joint Image Compression and Wireless Transmission Decoupled Descent: Exact Test Error Tracking Via Approximate Message Passing
Fundamental Bounds and Approaches to Sequence Reconstruct...
Jarek Duda, Wojciech Szpankowski, Ananth Grama · 2016-01-11 · via cs.IT updates on arXiv.org

Nanopore sequencers are emerging as promising new platforms for high-throughput sequencing. As with other technologies, sequencer errors pose a major challenge for their effective use. In this paper, we present a novel information theoretic analysis of the impact of insertion-deletion (indel) errors in nanopore sequencers. In particular, we consider the following problems: (i) for given indel error characteristics and rate, what is the probability of accurate reconstruction as a function of sequence length; (ii) what is the number of `typical' sequences within the distortion bound induced by indel errors; (iii) using replicated extrusion (the process of passing a DNA strand through the nanopore), what is the number of replicas needed to reduce the distortion bound so that only one typical sequence exists within the distortion bound. Our results provide a number of important insights: (i) the maximum length of a sequence that can be accurately reconstructed in the presence of indel and substitution errors is relatively small; (ii) the number of typical sequences within the distortion bound is large; and (iii) replicated extrusion is an effective technique for unique reconstruction. In particular, we show that the number of replicas is a slow function (logarithmic) of sequence length -- implying that through replicated extrusion, we can sequence large reads using nanopore sequencers. Our model considers indel and substitution errors separately. In this sense, it can be viewed as providing (tight) bounds on reconstruction lengths and repetitions for accurate reconstruction when the two error modes are considered in a single model.