The integrated sensing and communication (ISAC) problem with general state and channel distributions is investigated. General formulas of the capacity-distortion tradeoff for the ISAC problem under maximal and average distortion constraints are provided. The results cover some existing communication models such as the general point-to-point channel and Gel'fand-Pinsker channel. More details including memoryless states and channels, mixed states and channels, and rate-limited CSI at one side are considered. Numerical results focus on writing-on-dirty paper model and channel with ergodic/non-ergodic fading.