We study the impact of delayed channel state information at the transmitters (CSIT) in two-unicast wireless networks with a layered topology and arbitrary connectivity. We introduce a technique to obtain outer bounds to the degrees-of-freedom (DoF) region through the new graph-theoretic notion of bottleneck nodes. Such nodes act as informational bottlenecks only under the assumption of delayed CSIT, and imply asymmetric DoF bounds of the form $mD_1 + D_2 \leq m$. Combining this outer-bound technique with new achievability schemes, we characterize the sum DoF of a class of two-unicast wireless networks, which shows that, unlike in the case of instantaneous CSIT, the DoF of two-unicast networks with delayed CSIT can take an infinite set of values.