Trustworthiness assessment is an essential step to assure that interdependent systems perform critical functions as anticipated, even under adverse conditions. In this paper, a holistic trustworthiness assessment framework for ultra-wideband self-localization is proposed, including attributes of reliability, security, privacy, and resilience. Our goal is to provide guidance for evaluating a system's trustworthiness based on objective evidence, so-called trustworthiness indicators. These indicators are carefully selected through the threat analysis of the particular system. Our approach guarantees that the resulting trustworthiness indicators correspond to chosen real-world threats. Moreover, experimental evaluations are conducted to demonstrate the effectiveness of the proposed method. While the framework is tailored for this specific use case, the process itself serves as a versatile template, which can be used in other applications in the domains of the Internet of Things or cyber-physical systems.