Integrated sensing and communication is an important technology for sixth-generation (6G) mobile networks, enabling the joint use of communication and radar sensing within a unified system. While offering significant benefits in terms of spectral efficiency, ISAC introduces new security challenges. In particular, the joint use of resources for sensing and communication can increase vulnerability to eavesdropping and information leakage. In this paper, we study an uplink Non-Orthogonal Multiple Access (NOMA) system where the base station (BS) simultaneously receives user data and senses a potential eavesdropper (Eve) with uncertain location. To enhance the physical-layer security, a robust sensing signal is designed to both sense and jam Eve. We formulate a joint optimization problem that aims to maximize the users' sum rate and the BS sensing performance while maintaining security against Eve. Since the resulting optimization problem is non-convex, we develop an iterative alternating optimization (AO) algorithm that decomposes it into two tractable subproblems. In the first subproblem, the receive combining vectors are optimized in closed form using generalized eigenvalue decomposition. In the second subproblem, the transmit beamforming matrices and sensing power are jointly optimized via semidefinite relaxation (SDR) and successive convex approximation (SCA). Simulation results demonstrate the effectiveness of our solution in terms of fast convergence and resource allocation.