A low-power wearable wireless sensor measuring both molecular biomarkers and physiological signals is proposed, where the former are measured by a microfluidic biosensing system while the latter are measured electrically. The low-power consumption of the sensor is achieved by an all-analog circuit implementing Analog Joint Source-Channel Coding (AJSCC) compression. The sensor is applicable to a wide range of biomedical applications that require real-time concurrent molecular biomarker and physiological signal monitoring.