Orthogonal time frequency space (OTFS) is a promising waveform in high mobility scenarios for it fully exploits the time-frequency diversity using a discrete Fourier transform (DFT) based two dimensional spreading. However, it trades off the processing latency for performance and may not fulfill the stringent latency requirements in some services. This fact motivates us to design a hybrid frame structure where the OTFS and Orthogonal Frequency Division Multiplexing (OFDM) are orthogonally multiplexed in the time domain, which can adapt to both diversity-preferred and latency-preferred tasks. As we identify that this orthogonality is disrupted after channel coupling, we provide practical algorithms to mitigate the inter symbol interference between (ISI) the OTFS and OFDM, and the numerical results ensure the effectiveness of the hybrid frame structure.