We propose a new unsupervised and non-parametric method to detect change points in intricate quasi-periodic signals. The detection relies on optimal transport theory combined with topological analysis and the bootstrap procedure. The algorithm is designed to detect changes in virtually any harmonic or a partially harmonic signal and is verified on three different sources of physiological data streams. We successfully find abnormal or irregular cardiac cycles in the waveforms for the six of the most frequent types of clinical arrhythmias using a single algorithm. The validation and the efficiency of the method are shown both on synthetic and on real time series. Our unsupervised approach reaches the level of performance of the supervised state-of-the-art techniques. We provide conceptual justification for the efficiency of the method and prove the convergence of the bootstrap procedure theoretically.