This paper studies the semi-supervised novelty detection problem where a set of "typical" measurements is available to the researcher. Motivated by recent advances in multiple testing and conformal inference, we propose AdaDetect, a flexible method that is able to wrap around any probabilistic classification algorithm and control the false discovery rate (FDR) on detected novelties in finite samples without any distributional assumption other than exchangeability. In contrast to classical FDR-controlling procedures that are often committed to a pre-specified p-value function, AdaDetect learns the transformation in a data-adaptive manner to focus the power on the directions that distinguish between inliers and outliers. Inspired by the multiple testing literature, we further propose variants of AdaDetect that are adaptive to the proportion of nulls while maintaining the finite-sample FDR control. The methods are illustrated on synthetic datasets and real-world datasets, including an application in astrophysics.