Factor-adjusted multiple testing is used for handling strong correlated tests. Since most of previous works control the false discovery rate under sparse alternatives, we develop a two-step method, namely the AdaFAT, for any true false proportion. In this paper, the proposed procedure is adjusted by latent factor loadings. Under the existence of explanatory variables, a uniform convergence rate of the estimated factor loadings is given. We also show that the power of AdaFAT goes to one along with the controlled false discovery rate. The performance of the proposed procedure is examined through simulations calibrated by China A-share market.