We introduce three notions of multivariate median bias, namely, rectilinear, Tukey, and orthant median bias. Each of these median biases is zero under a suitable notion of multivariate symmetry. We study the coverage probabilities of rectangular hull of $B$ independent multivariate estimators, with special attention to the number of estimators $B$ needed to ensure a miscoverage of at most $α$. It is proved that for estimators with zero orthant median bias, we need $B\geq c\log_2(d/α)$ for some constant $c > 0$. Finally, we show that there exists an asymptotically valid (non-trivial) confidence region for a multivariate parameter $θ_0$ if and only if there exists a (non-trivial) estimator with an asymptotic orthant median bias of zero.