We study the fundamental problem of learning a single neuron, i.e., a function of the form $\mathbf{x}\mapstoσ(\mathbf{w}\cdot\mathbf{x})$ for monotone activations $σ:\mathbb{R}\mapsto\mathbb{R}$, with respect to the $L_2^2$-loss in the presence of adversarial label noise. Specifically, we are given labeled examples from a distribution $D$ on $(\mathbf{x}, y)\in\mathbb{R}^d \times \mathbb{R}$ such that there exists $\mathbf{w}^\ast\in\mathbb{R}^d$ achieving $F(\mathbf{w}^\ast)=ε$, where $F(\mathbf{w})=\mathbf{E}_{(\mathbf{x},y)\sim D}[(σ(\mathbf{w}\cdot \mathbf{x})-y)^2]$. The goal of the learner is to output a hypothesis vector $\mathbf{w}$ such that $F(\mathbb{w})=C\, ε$ with high probability, where $C>1$ is a universal constant. As our main contribution, we give efficient constant-factor approximate learners for a broad class of distributions (including log-concave distributions) and activation functions. Concretely, for the class of isotropic log-concave distributions, we obtain the following important corollaries: For the logistic activation, we obtain the first polynomial-time constant factor approximation (even under the Gaussian distribution). Our algorithm has sample complexity $\widetilde{O}(d/ε)$, which is tight within polylogarithmic factors. For the ReLU activation, we give an efficient algorithm with sample complexity $\tilde{O}(d\, \polylog(1/ε))$. Prior to our work, the best known constant-factor approximate learner had sample complexity $\tildeΩ(d/ε)$. In both of these settings, our algorithms are simple, performing gradient-descent on the (regularized) $L_2^2$-loss. The correctness of our algorithms relies on novel structural results that we establish, showing that (essentially all) stationary points of the underlying non-convex loss are approximately optimal.