Codifference is a commonly used measure of dependence for stable vectors and processes for which covariance is infinite. However, we argue that it can also be used for other heavy-tail distributions and it provides useful information for other non-Gaussian distributions as well, no matter the tails. Motivated by this, we analyse codifference using as little assumptions as possible about the studied model. It leads us to propose its natural domain and three natural variants of it. Using the wide class of variable scale mixture distributions we argue that the codifference can be interpreted as the measure of bulk properties which ignores the tails much more than the covariance. It can also detect forms of non-linear memory which covariance cannot. Finally, we show the asymptotic distribution of its estimator.