Let $M$ be a discrete-time normal martingale that has the chaotic representation property. Then, from the space of square integrable functionals of $M$, one can construct generalized functionals of $M$. In this paper, by using a type of weights, we introduce a class of continuous linear operators acting on generalized functionals of $M$, which we call generalized weighted number (GWN) operators. We prove that GWN operators can be represented in terms of generalized annihilation and creation operators (acting on generalized functionals of $M$). We also examine commutation relations between a GWN operator and a generalized annihilation (or creation) operator, and obtain several formulas expressing such commutation relations.