For a fixed degree sequence $\mathcal{D}=(d_1,...,d_n)$, let $G(\mathcal{D})$ be a uniformly chosen (simple) graph on $\{1,...,n\}$ where the vertex $i$ has degree $d_i$. In this paper we determine whether $G(\mathcal{D})$ has a giant component with high probability, essentially imposing no conditions on $\mathcal{D}$. We simply insist that the sum of the degrees in $\mathcal{D}$ which are not 2 is at least $λ(n)$ for some function $λ$ going to infinity with $n$. This is a relatively minor technical condition, and when $\mathcal{D}$ does not satisfy it, both the probability that $G(\mathcal{D})$ has a giant component and the probability that $G(\mathcal{D})$ has no giant component are bounded away from $1$.