We analyse the 2-dimensional Euler point vortices dynamics in the Koopman-Von Neumann approach. Classical results provide well-posedness of this dynamics involving singular interactions for a finite number of vortices, on a full-measure set with respect to the volume measure $dx^N$ on the phase space, which is preserved by the measurable flow thanks to the Hamiltonian nature of the system. We identify a core for the generator of the one-parameter group of Koopman-Von Neumann unitaries on $L^2(dx^N)$ associated to said flow, the core being made of observables smooth outside a suitable set on which singularities can occur.