In this article, we study the space-time SPDE $$ \partial_t^βu=-(-Δ)^{α/2} u+I_t^{1-β}[b(u)+σ(u)\dot{W}],$$ where $u=u(t,x)$ is defined for $(t,x)\in\mathbb{R}_+\times \mathbb{R},$ $β\in(0,1), α\in(0,2)$ and $\dot{W}$ denotes a space-time white noise. It has long been conjectured that this equation has a unique solution with finite moments under the minimal assumptions of locally Lipschitz coefficients $b$ and $σ$ with linear growth. We prove that this SPDE is well-posed under the assumptions that the initial condition $u_0$ is bounded and measurable, and the functions $b$ and $σ$ are locally Lipschitz and have at-most linear growth and some conditions on the Lipschitz constants on the truncated versions of $b$ and $σ$. Our results generalize the work of Foondun et al.(2025) to a space-time fractional setting.