We prove the existence of optimal separators for intersection graphs of balls and spheres in any dimension $d$. One of our results is that if an intersection graph of $n$ spheres in $\mathbb{R}^d$ has $m$ edges, then it contains a balanced separator of size $O_d(m^{1/d}n^{1-2/d})$. This bound is best possible in terms of the parameters involved. The same result holds if the balls and spheres are replaced by fat convex bodies and their boundaries.