In the Maker-Breaker resolving game, two players named Resolver and Spoiler alternately select unplayed vertices of a given graph $G$. The aim of Resolver is to select all the vertices of some resolving set of $G$, while Spoiler aims to select at least one vertex from every resolving set of $G$. In this paper, this game is investigated on the lexicographic product of graphs. It is proved that if Spoiler has a winning strategy on a graph $H$ no matter who starts the game, or if the first player has a winning strategy on $H$, then Spoiler always has a winning strategy on $G\circ H$. Special attention is paid to lexicographic products in which the second factor is either complete, or a path, or a cycle. For instance, in $G\circ P_{2\ell}$ and in $G\circ C_{2\ell}$, Resolver always wins, while in $G\circ P_{2\ell+1}$ and in $G\circ C_{2\ell+1}$ the same conclusion holds provided $G$ is free from false twins. On the other hand, Spoiler always wins on $G\circ P_5$. In most of the cases, the corresponding Maker-Breaker resolving number is also determined.