Let $(S,M,U)$ be a marked orbifold with or without punctures and let $\mathcal A_v$ be a quantum cluster algebra from $(S,M,U)$ with arbitrary coefficients and quantization. We provide combinatorial formulas for quantum Laurent expansion of quantum cluster variables of $\mathcal A_v$ concerning an arbitrary quantum seed. Consequently, the positivity for the quantum cluster algebra $\mathcal A_v$ is proved.