This paper introduces Generalized Nonnegative Structured Kruskal Tensor Regression (NS-KTR), a novel tensor regression framework that enhances interpretability and performance through mode-specific hybrid regularization and nonnegativity constraints. Our approach accommodates both linear and logistic regression formulations for diverse response variables while addressing the structural heterogeneity inherent in multidimensional tensor data. We integrate fused LASSO, total variation, and ridge regularizers, each tailored to specific tensor modes, and develop an efficient alternating direction method of multipliers (ADMM) based algorithm for parameter estimation. Comprehensive experiments on synthetic signals and real hyperspectral datasets demonstrate that NS-KTR consistently outperforms conventional tensor regression methods. The framework's ability to preserve distinct structural characteristics across tensor dimensions while ensuring physical interpretability makes it especially suitable for applications in signal processing and hyperspectral image analysis.