We propose a new approach to falsify causal discovery algorithms without ground truth, which is based on testing the causal model on a pair of variables that has been dropped when learning the causal model. To this end, we use the "Leave-One-Variable-Out (LOVO)" prediction where $Y$ is inferred from $X$ without any joint observations of $X$ and $Y$, given only training data from $X,Z_1,\dots,Z_k$ and from $Z_1,\dots,Z_k,Y$. We demonstrate that causal models on the two subsets, in the form of Acyclic Directed Mixed Graphs (ADMGs), often entail conclusions on the dependencies between $X$ and $Y$, enabling this type of prediction. The prediction error can then be estimated since the joint distribution $P(X, Y)$ is assumed to be available, and $X$ and $Y$ have only been omitted for the purpose of falsification. After presenting this graphical method, which is applicable to general causal discovery algorithms, we illustrate how to construct a LOVO predictor tailored towards algorithms relying on specific a priori assumptions, such as linear additive noise models. Simulations indicate that the LOVO prediction error is indeed correlated with the accuracy of the causal outputs, affirming the method's effectiveness.