Autism Spectrum Disorder (ASD), which is a neuro development disorder, is often accompanied by sensory issues such an over sensitivity or under sensitivity to sounds and smells or touch. Although its main cause is genetics in nature, early detection and treatment can help to improve the conditions. In recent years, machine learning based intelligent diagnosis has been evolved to complement the traditional clinical methods which can be time consuming and expensive. The focus of this paper is to find out the most significant traits and automate the diagnosis process using available classification techniques for improved diagnosis purpose. We have analyzed ASD datasets of Toddler, Child, Adolescent and Adult. We determine the best performing classifier for these binary datasets using the evaluation metrics recall, precision, F-measures and classification errors. Our finding shows that Sequential minimal optimization (SMO) based Support Vector Machines (SVM) classifier outperforms all other benchmark machine learning algorithms in terms of accuracy during the detection of ASD cases and produces less classification errors compared to other algorithms. Also, we find that Relief Attributes algorithm is the best to identify the most significant attributes in ASD datasets.