Teamwork is one of the most prominent features in modern science. It is now well-understood that the team size is an important factor that affects team creativity. However, the crucial question of how the character of research studies is influenced by the freshness of the team remains unclear. In this paper, we quantify the team freshness according to the absent of prior collaboration among team members. Our results suggest that fresher teams tend to produce works of higher originality and more multi-disciplinary impact. These effects are even magnified in larger teams. Furthermore, we find that freshness defined by new team members in a paper is a more effective indicator of research originality and multi-disciplinarity compared to freshness defined by new collaboration relations among team members. Finally, we show that career freshness of members also plays an important role in increasing the originality and multi-disciplinarity of produced papers.