Cyber-Physical Production Systems (CPPSs), such as automated car manufacturing plants, execute a configurable sequence of production steps to manufacture products from a product portfolio. In CPPS engineering, domain experts start with manually determining feasible production step sequences and resources based on implicit knowledge. This process is hard to reproduce and highly inefficient. In this paper, we present the Extended Iterative Process Sequence Exploration (eIPSE) approach to derive variability models for products, processes, and resources from a domain-specific description. To automate the integrated exploration and configuration process for a CPPS, we provide a toolchain which automatically reduces the configuration space and allows to generate CPPS artifacts, such as control code for resources. We evaluate the approach with four real-world use cases, including the generation of control code artifacts, and an observational user study to collect feedback from engineers with different backgrounds. The results confirm the usefulness of the eIPSE approach and accompanying prototype to straightforwardly configure a desired CPPS.