Modern highly automated and autonomous traffic systems and subsystems require new approaches to test their functional safety in the context of validation and verification. One approach that has taken a leading role in current research is scenario-based testing. For various reasons, simulation is considered to be the most practicable solution for a wide range of test scenarios. However, this is where many existing simulation systems in research reach their limits. In order to be able to integrate the widest possible range of systems to be tested into the simulation, the use of co-simulation has proven to be particularly useful. In this work, the High Level Architecture defined in the IEEE 1516-2010 standard is specifically addressed and a concept is developed that establishes the foundation for the feasible use of scenario-based distributed co-simulation on its basis. The main challenge identified and addressed is the resolution of the double-sided dependency between scenario and simulation models. The solution was to fully automate the generation and instantiation of the simulation environment on the basis of a scenario instance. Finally, the developed concept was implemented as a prototype and the resulting process for its use is presented here using an example scenario. Based on the experience gained during the creation of the concept and the prototype, the next steps for future work are outlined in conclusion.