Learning-based program repair has achieved good results in a recent series of papers. Yet, we observe that the related work fails to repair some bugs because of a lack of knowledge about 1) the application domain of the program being repaired, and 2) the fault type being repaired. In this paper, we solve both problems by changing the learning paradigm from supervised training to self-supervised training in an approach called SelfAPR. First, SelfAPR generates training samples on disk by perturbing a previous version of the program being repaired, enforcing the neural model to capture projectspecific knowledge. This is different from the previous work based on mined past commits. Second, SelfAPR executes all training samples and extracts and encodes test execution diagnostics into the input representation, steering the neural model to fix the kind of fault. This is different from the existing studies that only consider static source code as input. We implement SelfAPR and evaluate it in a systematic manner. We generate 1 039 873 training samples obtained by perturbing 17 open-source projects. We evaluate SelfAPR on 818 bugs from Defects4J, SelfAPR correctly repairs 110 of them, outperforming all the supervised learning repair approaches.