We introduce DeSTA2.5-Audio, a general-purpose Large Audio Language Model (LALM) designed for robust auditory perception and instruction-following. Recent LALMs augment Large Language Models (LLMs) with auditory capabilities by training on large-scale audio-instruction datasets. However, existing LALMs have often suffered from the catastrophic forgetting of the LLM's original abilities. Therefore, balancing knowledge retention and audio perception has become a critical challenge. To address this, we revisit the data construction pipeline and propose a self-generated cross-modal alignment strategy in which the backbone LLM generates its own training targets, named DeSTA. This approach aims at preserving the LLM's native language proficiency thereby enabling zero-shot generalization without task-specific tuning. We construct DeSTA-AQA5M, a large-scale, task-agnostic dataset containing 5 million training samples derived from 7,000 hours of audio spanning 50 diverse datasets, including speech, environmental sounds, and music. DeSTA2.5-Audio achieves state-of-the-art or competitive performance across a wide range of audio-language benchmarks, including Dynamic-SUPERB, MMAU, SAKURA, Speech-IFEval, and VoiceBench. Comprehensive comparative studies demonstrate that our self-generated strategy outperforms existing training strategies. Our findings underscore the importance of carefully designed data construction in LALM development and offer practical insights for building robust, general-purpose LALMs.