This paper explores the efficacy of Mel Frequency Cepstral Coefficients (MFCCs) in detecting abnormal heart sounds using two classification strategies: a single classifier and an ensemble classifier approach. Heart sounds were first pre-processed to remove noise and then segmented into S1, systole, S2, and diastole intervals, with thirteen MFCCs estimated from each segment, yielding 52 MFCCs per beat. Finally, MFCCs were used for heart sound classification. For that purpose, in the single classifier strategy, the MFCCs from nine consecutive beats were averaged to classify heart sounds by a single classifier (either a support vector machine (SVM), the k nearest neighbors (kNN), or a decision tree (DT)). Conversely, the ensemble classifier strategy employed nine classifiers (either nine SVMs, nine kNN classifiers, or nine DTs) to individually assess beats as normal or abnormal, with the overall classification based on the majority vote. Both methods were tested on a publicly available phonocardiogram database. The heart sound classification accuracy was 91.95% for the SVM, 91.9% for the kNN, and 87.33% for the DT in the single classifier strategy. Also, the accuracy was 93.59% for the SVM, 91.84% for the kNN, and 92.22% for the DT in the ensemble classifier strategy. Overall, the results demonstrated that the ensemble classifier strategy improved the accuracies of the DT and the SVM by 4.89% and 1.64%, establishing MFCCs as more effective than other features, including time, time-frequency, and statistical features, evaluated in similar studies.