Multimodal immersive spatial drama generation focuses on creating continuous multi-speaker binaural speech with dramatic prosody based on multimodal prompts, with potential applications in AR, VR, and others. This task requires simultaneous modeling of spatial information and dramatic prosody based on multimodal inputs, with high data collection costs. To the best of our knowledge, our work is the first attempt to address these challenges. We construct MRSDrama, the first multimodal recorded spatial drama dataset, containing binaural drama audios, scripts, videos, geometric poses, and textual prompts. Then, we propose ISDrama, the first immersive spatial drama generation model through multimodal prompting. ISDrama comprises these primary components: 1) Multimodal Pose Encoder, based on contrastive learning, considering the Doppler effect caused by moving speakers to extract unified pose information from multimodal prompts. 2) Immersive Drama Transformer, a flow-based mamba-transformer model that generates high-quality drama, incorporating Drama-MOE to select proper experts for enhanced prosody and pose control. We also design a context-consistent classifier-free guidance strategy to coherently generate complete drama. Experimental results show that ISDrama outperforms baseline models on objective and subjective metrics. The demos are available at https://aaronz345.github.io/ISDramaDemo. We provide the dataset and the evaluation code at https://huggingface.co/datasets/AaronZ345/MRSDrama and https://github.com/AaronZ345/ISDrama.