Integrated sensing and communication (ISAC) enables simultaneous localization, environment perception, and data exchange for connected autonomous vehicles. However, most existing ISAC designs prioritize sensing accuracy and communication throughput, treating all targets uniformly and overlooking the impact of critical obstacles on motion efficiency. To overcome this limitation, we propose a planning-oriented ISAC (PISAC) framework that reduces the sensing uncertainty of planning-bottleneck obstacles and expands the safe navigable path for the ego-vehicle, thereby bridging the gap between physical-layer optimization and motion-level planning. The core of PISAC lies in deriving a closed-form safety bound that explicitly links ISAC transmit power to sensing uncertainty, based on the Cramér-Rao Bound and occupancy inflation principles. Using this model, we formulate a bilevel power allocation and motion planning (PAMP) problem, where the inner layer optimizes the ISAC beam power distribution and the outer layer computes a collision-free trajectory under uncertainty-aware safety constraints. Comprehensive simulations in high-fidelity urban driving environments demonstrate that PISAC achieves up to 40% higher success rates and over 5% shorter traversal times than existing ISAC-based and communication-oriented benchmarks, validating its effectiveness in enhancing both safety and efficiency.