In recent years, general matrix-matrix multiplication with non-regular-shaped input matrices has been widely used in many applications like deep learning and has drawn more and more attention. However, conventional implementations are not suited for non-regular-shaped matrix-matrix multiplications, and few works focus on optimizing tall-and-skinny matrix-matrix multiplication on CPUs. This paper proposes an auto-tuning framework, AutoTSMM, to build high-performance tall-and-skinny matrix-matrix multiplication. AutoTSMM selects the optimal inner kernels in the install-time stage and generates an execution plan for the pre-pack tall-and-skinny matrix-matrix multiplication in the runtime stage. Experiments demonstrate that AutoTSMM achieves competitive performance comparing to state-of-the-art tall-and-skinny matrix-matrix multiplication. And, it outperforms all conventional matrix-matrix multiplication implementations.